To localize wheat ESTs on chromosomes, 882 homoeologous group 6-specific ESTs were identified by physically mapping 7965 singletons from 37 cDNA libraries on 146 chromosome, arm, and sub-arm aneuploid and deletion stocks. The 882 ESTs were physically mapped to 25 regions flanked by 23 deletion breakpoints. Of the 5154 restriction fragments detected by 882 ESTs, 2043 were localized to group 6 chromosomes and 806 were mapped on other chromosome groups. The number of loci mapped was greatest on chromosome 6B and (...) least on 6D. The 264 ESTs that detected orthologous loci on all three homoeologs using one restriction enzyme were used to construct a consensus physical map. The physical distribution of ESTs was uneven on chromosomes with a tendency toward higher densities in the distal halves of chromosome arms. About 43% of the wheat group 6 ESTs identified rice homologs upon comparisons of genome sequences. Fifty-eight percent of these ESTs were present on rice chromosome 2 and the remaining were on other rice chromosomes. Even within the group 6 bins, rice chromosomal blocks identified by 1-6 wheat ESTs were homologous to up to 11 rice chromosomes. These rice-block contigs were used to resolve the order of wheat ESTs within each bin. (shrink)

FOIS is the flagship conference of the International Association for Ontology and its Applications, a non-profit organization which promotes interdisciplinary research and international collaboration at the intersection of philosophical ontology, linguistics, logic, cognitive science, and computer science. This book presents the papers delivered at FOIS 2023, the 13th edition of the Formal Ontology in Information Systems conference. The event was held as a sequentially-hybrid event, face-to-face in Sherbrooke, Canada, from 17 to 20 July 2023, and online from 18 to 20 (...) September 2023. In total, 62 articles from 19 different countries were submitted, out of which 25 were accepted for inclusion in the conference and for publication; corresponding to an acceptance rate of 40 percent. The contributions are separated into the book’s three sections: (1) Foundational ontological issues; (2) Methodological issues around the development, alignment, verification and use of ontologies; and (3) Domain ontologies and ontology-based applications. In these sections, ontological aspects from a wide variety of fields are covered, primarily from various engineering domains including cybersecurity, manufacturing, petroleum engineering, and robotics, but also extending to the humanities, social sciences, medicine, and dentistry. A noticeable trend among the contributions in this edition of the conference is the recognition that improving the tools to analyze, align, and improve ontologies is of paramount importance in continuing to advance the field of formal ontology. The book will be of interest to all formal and applied ontology researchers, and to those who use formal ontologies and information systems as part of their work. (shrink)

The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region of the (...) chromosome arms, with the exception of 3DS and 3DL. These distributions were more localized on the higher-resolution group 3 consensus map with intermediate regions of high-mapped-EST density on both chromosome arms. Gene ontology classification of mapped ESTs was not significantly different for homoeologous group 3 chromosomes compared to the other groups. A combined analysis of the individual bin maps using 537 of the mapped ESTs revealed rearrangements between the group 3 chromosomes. Approximately 232 of the consensus mapped ESTs matched sequences on rice chromosome 1 and revealed large- and small-scale differences in gene order. Of the group 3 mapped EST unigenes ∼21 and 32% matched the Arabidopsis coding regions and proteins, respectively, but no chromosome-level gene order conservation was detected. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated loci (...) in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

We investigate how a group of players might cooperate with each other within the setting of a non-cooperative game. We pursue two notions of partial cooperative equilibria that follow a modification of Nash’s best response rationality rather than a core-like approach. Partial cooperative Nash equilibrium treats non-cooperative players and the coalition of cooperators symmetrically, while the notion of partial cooperative leadership equilibrium assumes that the group of cooperators has a first-mover advantage. We prove existence theorems for both types of equilibria. (...) We look at three well-known applications under partial cooperation. In a game of voluntary provision of a public good we show that our two new equilibrium notions of partial cooperation coincide. In a modified Cournot oligopoly, we identify multiple equilibria of each type and show that a non-cooperator may have a higher payoff than a cooperator. In contrast, under partial cooperation in a symmetric Salop City game, a cooperator enjoys a higher return. (shrink)

A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

A total of 944 expressed sequence tags generated 2212 EST loci mapped to homoeologous group 1 chromosomes in hexaploid wheat. EST deletion maps and the consensus map of group 1 chromosomes were constructed to show EST distribution. EST loci were unevenly distributed among chromosomes 1A, 1B, and ID with 660, 826, and 726, respectively. The number of EST loci was greater on the long arms than on the short arms for all three chromosomes. The distribution of ESTs along chromosome arms (...) was nonrandom with EST clusters occurring in the distal regions of short arms and middle regions of long arms. Duplications of group 1 ESTs in other homoeologous groups occurred at a rate of 35.5%. Seventy-five percent of wheat chromosome 1 ESTs had significant matches with rice sequences, where large regions of conservation occurred between wheat consensus chromosome 1 and rice chromosome 5 and between the proximal portion of the long arm of wheat consensus chromosome 1 and rice chromosome 10. Only 9.5% of group 1 ESTs showed significant matches to Arabidopsis genome sequences. The results presented are useful for gene mapping and evolutionary and comparative genomics of grasses. (shrink)

BackgroundCentral to ethically justified clinical trial design is the need for an informed consent process responsive to how potential subjects actually comprehend study participation, especially study goals, risks, and potential benefits. This will be particularly challenging when studying deep brain stimulation and whether it impedes symptom progression in Parkinson’s disease, since potential subjects will be Parkinson’s patients for whom deep brain stimulation will likely have therapeutic value in the future as their disease progresses.MethodAs part of an expanded informed consent process (...) for a pilot Phase I study of deep brain stimulation in early stage Parkinson’s disease, an ethics questionnaire composed of 13 open-ended questions was distributed to potential subjects. The questionnaire was designed to guide potential subjects in thinking about their potential participation.ResultsWhile the purpose of the study (safety and tolerability) was extensively presented during the informed consent process, in returned responses 70 percent focused on effectiveness and 91 percent included personal benefit as potential benefit from enrolling. However, 91 percent also indicated helping other Parkinson’s patients as motivation when considering whether or not to enroll.ConclusionsThis combination of responses highlights two issues to which investigators need to pay close attention in future trial designs: (1) how, and in what ways, informed consent processes reinforce potential subjects’ preconceived understandings of benefit, and (2) that potential subjects see themselves as part of a community of Parkinson’s sufferers with responsibilities extending beyond self-interest. More importantly, it invites speculation that a different paradigm for informed consent may be needed. (shrink)

Reason and quest for revelation, by P. Tillich.--On the ontological mystery, by G. Marcel.--The problem of non-objectifying thinking and speaking, by M. Heidegger.--The problem of natural theology, by J. Macquarrie.--Metaphysical rebellion, by A. Camus.--Psychoanalysis and religion by E. Fromm.--Why I am not a Christian, by B. Russell.--The quest for being, by S. Hook.--The sacred and the profane; a dialectical understanding of Christianity, by T. J. J. Altizer.--Three strata of meaning in religious discourse by C. Hartshorne.--The theological task, by J. B. (...) Cobb.--Theology and objectivity, by S. A. Ogden.--Can faith validate God-talk? by K. Nielsen.--The logic of God, by J. Wisdom.--Mapping the logic of models in science and theology, by F. Ferré.--On understanding mystery, by I. T. Ramsey.--Teilhard de Chardin; a philosophy of precession, by E. R. Baltazar.--The nature of apologetics, by H. Bouillard.--Metaphysics as horizon, by B. Lonergan.--Deciding whether to believe, by M. Novak. (shrink)

In this paper, we report on a new approach to relativistic quantum theory. The classical theory is derived from a new implementation of the first two postulates of Einstein, which fixes the proper-time of the physical system of interest for all observers. This approach leads to a new group that we call the proper-time group. We then construct a canonical contact transformation on extended phase space to identify the canonical Hamiltonian associated with the proper-time variable. On quantization we get a (...) new relativistic wave equation for spin 1/2 particles that generalizes the Dirac theory. The Hamiltonian is positive definite so we naturally interpret antiparticles as particles with their proper-time reversed. We show that for the hydrogen atom problem, we get the same fine structure separation. When the proton spin magnetic moment is taken into account, we get the standard hyperfine splitting terms of the Pauli approximation and two additional terms. The first term is small in p-states. It diverges in s-states, and provides more than enough to account for the Lamb-shift when the proton radius is used as a cut off. The last term promises to provide a correction to the hyperfine splitting term. Although incomplete, the general approach offers hope of completely accounting for the hydrogen spectrum as an eigenvalue problem. (shrink)

Tensions, Réformes et Recherche du consensus: Vatican II dans l’itinéraire de l’Église catholique au XXe siècle (Tensions, reforms and consensus : Vatican II in the itinerary of the Catholic Church in the twentieth century) Résumé Contrairement à ce que l’on affirme parfois, les tensions que l’on retrouve dans l’Église catholique au moment de la réception du concile ne sont pas nées avec le concile, mais s’enracinent au cours du siècle qui précéda Vatican II. Elles portent principalement sur le rapport de (...) l’Église catholique au monde moderne. À Vatican II, si les Pères conciliaires ont été d’accord pour généraliser et accélérer l’effort de mise à jour de l’Église entamée depuis quelques décennies, quelques-uns ont refusé le discernement opéré par l’Église catholique sur l’enseignement des papes, depuis Pie IX, sur le rapport de l’Église avec le monde moderne. Les évêques appartenant à la majorité ont estimé qu’il fallait re-recevoir ces enseignements portés dans des circonstances historiques différentes, et les apprécier à la lumière des situations nouvelles dans lesquelles évoluait désormais l’Église catholique. L’opposition actuelle au concile refuse ce discernement et voudrait, par-delà le concile, revenir aux positions tenues au XIXe siècle. Mots-clés : Vatican II; L’Église Catholique. XX e siècle. Tensions. Réformes. ConsensusTo the contrary of what is commonly said, the tensions in the Catholic Church at the time of reception of the Council did not originate within the council, but are rooted in the course of the century prior to Vatican II. These tensions relate mainly to the relationship of the Catholic Church with the modern world. If the Fathers of the Second Vatican agreed to upgrade the Church, after a few decades some priests refused to follow the teachings of the Popes about the relationship of the Church with the modern world. Most bishops felt that they should return to those teachings used in different historical circumstances, and evaluate them in light of the context of the new changes in the world. The current opposition to the council refuses this insight or judgement and wants to go back to the positions of the Church of the nineteenth century. Keywords : Vatican II; Catholic Church. Twentieth Century. Tensions. Reforms. Consensus. (shrink)

I am grateful to the editors of the Canadian Journal of Philosophy for inviting me to write a comment on Kathleen Gill’s ‘On the Metaphysical Distinction Between Processes and Events’. I readily concede that she is right in the central criticism she makes of my 1978 paper: that a properly metaphysical or ontological distinction between processes and events, if it is to be made at all, cannot be sustained on the basis of the informal linguistic criteria I offered in (...) ‘Events, Processes, and States.’ My main concern in that paper was to show that discussions of the Kenny-Vendler typology of activities, performances, and states had focused too narrowly on verb types, on adverbial phrases, on the domain of human action, and on English-language intuitions. Mine was one of several voices urging in the late 1970s that issues of tense logic and of the logic of verb types had to be placed in the broader context of verb aspect — a salient and pervasive structure in natural languages generally, and one that had been studied by philologists and linguists since the nineteenth century. Captivated, as I and others had become at the time, by evidence that the distinction between count nouns and mass nouns appears to be mirrored in verb predications, I went on to make some rather venturesome ‘ontological’ claims. It is satisfying, of course, that Gill accepts not only that there is ‘substantial evidence in favor of recognizing a grammatical distinction between the language of processes and [the language of] events’ but also that ‘similarities with count and mass expressions will allow us to apply techniques for han dling nominal expressions to verbal expressions’. It is more than satisfying that the phenomenon of verb aspect is now noticed and investigated by philosophers as well as by linguists. (shrink)

Some argue that it is ethically justifiable to unilaterally withdraw life‐sustaining treatment during crisis standards of care without the patient's consent in order to reallocate it to another patient with a better chance of survival. This justification has been supported by two lines of argument: the equivalence thesis and the rule of the double effect. We argue that there are theoretical issues with the first and practical ones with the second, as supported by an experiment aimed at exploring whether the (...) Knobe effect, which affects the folk concept of intention, applies to situations of unilateral withdrawal. Fifty‐two critical care physicians from one university were asked to ascribe intention in two hypothetical scenarios A and B in which outcomes differ—the patient from whom life‐sustaining treatment is withdrawn dies in scenario A but survives in scenario B—but the intention, to save the other patient regardless of the outcome of the other, is the same. The survey was administered via a web‐based survey and all answers were anonymous. A paired proportion test was used to compare responses to both questions. All 52 surveyed individuals responded in scenario A and 30 (57.7%) ascribed intention when outcomes were unfavorable, whereas 50 responded in scenario B and 8 (16%) ascribed intention when outcomes were favorable, a difference that was statistically significant (p < 0.001). There are theoretical and practical issues with the arguments proposed to justify the unilateral withdrawal of life‐sustaining treatment based on the equivalence thesis and the rule of double effect. (shrink)

At once feared and revered, sharks have captivated people since our earliest human encounters. Children and adults alike stand awed before aquarium shark tanks, fascinated by the giant teeth and unnerving eyes. And no swim in the ocean is undertaken without a slight shiver of anxiety about the very real—and very cinematic—dangers of shark bites. But our interactions with sharks are not entirely one-sided: the threats we pose to sharks through fisheries, organized hunts, and gill nets on coastlines are (...) more deadly and far-reaching than any bite. In Sharks and People acclaimed wildlife photographer Thomas Peschak presents stunning photographs that capture the relationship between people and sharks around the globe. A contributing photographer to National Geographic, Peschak is best known for his unusual photographs of sharks—his iconic image of a great white shark following a researcher in a small yellow kayak is one of the most recognizable shark photographs in the world. The other images gathered here are no less riveting, bringing us as close as possible to sharks in the wild. Alongside the photographs, Sharks and People tells the compelling story of the natural history of sharks. Sharks have roamed the oceans for more than four hundred million years, and in this time they have never stopped adapting to the ever-changing world—their unique cartilage skeletons and array of super-senses mark them as one of the most evolved groups of animals. Scientists have recently discovered that sharks play an important role in balancing the ocean, including maintaining the health of coral reefs. Yet, tens of millions of sharks are killed every year just to fill the demand for shark fin soup alone. Today more than sixty species of sharks, including hammerhead, mako, and oceanic white-tip sharks, are listed as vulnerable or in danger of extinction. The need to understand the significant part sharks play in the oceanic ecosystem has never been so urgent, and Peschak’s photographs bear witness to the thrilling strength and unique attraction of sharks. They are certain to enthrall and inspire. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Euripides' Escape-Tragedies: A Study of Helen, Andromeda, and Iphigenia among the TauriansHelene P. FoleyMatthew Wright. Euripides' Escape-Tragedies: A Study of Helen, Andromeda, and Iphigenia among the Taurians. Oxford: Oxford University Press, 2005. viii + 433 pp. Cloth, $125.Due to their putatively lighter tone, exotic foreign settings, and concluding "resolutions" of past misfortunes, Euripides' Helen, fragmentary Andromeda, and Iphigenia Among the Taurians (henceforth IT) have often been described as (...) proto-romances or tragi-comedies. Wright's study follows recent trends in defining ancient Greek dramatic genres above all through their performance context; he argues that the plays belong firmly in the tragic camp and develop serious philosophical and religious themes that deliberately leave their audience in a state of aporia. The plots of these plays share an escape from disaster/remote and threatening environments. Although we cannot firmly date IT, Wright tries to make the case that these apparently unique shared elements suggest that the plays were performed as a coherent trilogy in 412 B.C.E. The book does not [End Page 465] attempt to address in detail many aspects of these (relatively neglected) plays that have been extensively discussed by other critics. Instead Wright focuses on the plays' generic status, their possible mythical innovations, their remote settings, and their philosophy and theology.Although there are many unusual mythical elements in these plays, Wright makes a detailed case that Euripides most probably recombined elements previously known in the tradition to a novel effect, rather than inventing them. He casts considerable doubt on Stesichorus' palinode and Herodotus as origins for Euripides' innocent Egyptian Helen, however. Wright challenges previous assumptions by arguing that Euripides does not develop the plays' barbarian settings. Indeed, there is little ethnic or geographical detail beyond a few initial sketchy references, and the plays blur the differences between Greeks and barbarian "others." The Egyptians Proteus, Theoclymenus, and Theonoe are, genealogically speaking, Greek (183). After a lengthy discussion of the problems of defining philosophical elements in tragedy, Wright links the plays' extensive treatment of the unreliable nature of human language and knowledge of reality to discussions of comparable themes in the fragments of the Sophists, especially Gorgias and Democritus. Finally, Wright argues that the plays, by stressing the impossibility of understanding the divine forces that govern the universe, represent an unusually bleak theological picture. The dei ex machina that conclude Helen and IT belatedly outline mysterious divine patterns governing the confusing dramatic events, but humans can only repeatedly misinterpret their experience and name the divine forces governing their lives, erroneously in Wright's view, as tuche\.These issues, above all the themes of illusion and reality and the nature of divinity in the plays, have in fact been discussed before, but Wright attempts a fuller (with the exception of his attenuated discussion of ritual) and methodologically tighter discussion. This represents both the book's strength and weakness. Without its exhaustive review of dated and (putatively) weakly argued earlier critical views, the book could, and in my view ideally should, have made its positive case more forcefully in half the length. At the same time, by failing to engage with important earlier treatments of central topics, Wright leaves the reader with the impression that scholarly work on these issues is far less nuanced than it has in fact been. To give a few examples that he neglects altogether, his discussion of Aristophanes' parody of Euripides in Thesmophoriazusae (120, n. 196; see also 50–51) does not take advantage of Zeitlin's seminal article on the topic ("Travesties of Gender and Genre in Aristophanes' Thesmophoriazusae," published most recently in her Playing the Other: Gender and Society in Classical Greek Literature [Chicago, 1996], 375–416); he does not make use of John H. Finley's extensive study of Euripides, Thucydides, and the sophists (Three Essays on Thucydides, [Cambridge, Mass., 1967]); other important methodologically sophisticated work on philosophy and tragedy, such as that of Mary Whitlock Blundell (Helping Friends and Harming Enemies: A Study in Sophocles and Greek Ethics [Cambridge, 1989]) or Christopher Gill (Personality in Greek Epic, Tragedy, and Philosophy: The Self in Dialogue [Oxford, 1996]), does not even appear in the notes. [End Page 466... (shrink)

This paper draws upon Deleuze and Guattari's ideas to suggest a different kind of reading of a narrative of a mother of a child with severe disability, and thus a different kind of ethical response to them. This reading gives readers the possibility of opening up experiences of parents and children with disability, rather than compartmentalising such stories. The reader becomes, is transformed, through reading these narratives and through engaging with the intensities which are recognised in the text, asking the (...) question ‘Does it work for me?’ This is what Gilles Deleuze calls ‘reading with love’. (shrink)

What is the difference between doing philosophy and doing the history of philosophy? Where should the line be drawn between ?using? previous philosophers to make one's point and discussing what past philosophers claimed? In trying to confront these questions, this essay starts with a reflection on the difference between doing philosophy and doing the history of philosophy as proposed by the French philosopher Gilles Deleuze, and confronts it with a different one derived from the German philosopher Martin Heidegger. The ideas (...) developed by Heidegger will then lead to a definition of ?philosophy? and to some etymology-based reflections on what a ?philosopher? is that Plato proposes in his ?Symposium?. The essay continues by arguing that, when doing philosophy, it is necessary to return to philosophy's past in order to recoup philosophical momentum. The essay concludes with some reflection on the possible similarities between Plato's characterization of Eros as the first philosopher and the difference between doing philosophy and doing the history of philosophy. (shrink)

Les décisions politiques sur les risques environnementaux complexes font fréquemment intervenir des éléments scientifiques contestés. Il n’y a généralement pas de « faits » qui conduisent à une politique correcte unique. Les éléments de preuve qui sont intégrés dans les avis scientifiques destinés à une décision politique nécessitent une évaluation de leur qualité. En 2003, l’Agence néerlandaise d’évaluation environnementale a adopté une méthode standardisée, désignée sous le nom de « guide », dans le cadre de laquelle les principaux aspects de (...) la production et de l’utilisation des connaissances sont présentés grâce à une liste de contrôle visant à l’évaluation et à la communication des incertitudes. Dans cet article, nous présentons des résultats de l’application de ce guide à la controverse sur les risques des particules en suspension. La délibération active sur l’incertitude dans un contexte d’expertise entraîne un processus d’apprentissage commun entre les experts et les décideurs politiques, ce qui conduit à une meilleure prise de conscience du phénomène d’incertitude et de ses implications politiques.Policy decisions on complex environmental risks often involve disputed science. Typically, there are no “ facts” to support a single unequivocally correct policy. The evidence provided in scientific studies for policy-making decisions requires high-quality assessment. In 2003, the Netherlands Environmental Assessment Agency adopted a standardized method, referred to as “guidelines”, whereby key quality aspects of knowledge production and use are presented in the form of a checklist for uncertainty assessments and communication. In this article, we present the outcomes of applying the guidelines in controversies on the risks of ambient particulate matter. In the policy–advisory context, active deliberation on uncertainty produces a common learning process for advisors and policy makers, which leads to a deeper understanding and increased awareness of the phenomenon of uncertainty and its policy implications. (shrink)

The manifold phenomena of love exhibited in diverse human societies during different periods of recorded history are rooted in biological features of human beings. The human procreative urge among women is natural to our species. Maternal love is rooted in mammalian nature. The ideal love of a mother for her child is a common transcultural paradigm of selflessness. This chapter first examines the biological roots of love and subsequently to the social constraints within which its various forms are possible. It (...) then discusses the multiple kinds of possible objects of love and the threads connecting them, and explains the framework of moral, social, and legal norms within which human love is realized. Love is a paradigm of a developing emotion. Being in love is the natural sequel to falling in love. It involves wanting to be with the person loved, a strong desire to please, to share experience, and to delight in shared experiences. (shrink)